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RepairSig: Deconvolution of DNA damage and repair contributions to the mutational landscape of cancer.

Cell systems - 20 Oct 2021

Wojtowicz Damian, Hoinka Jan, Amgalan Bayarbaatar, Kim Yoo-Ah, Przytycka Teresa M

Abstract excerpt

Cancer genomes accumulate a large number of somatic mutations resulting from a combination of stochastic errors in DNA processing, cancer-related aberrations of the DNA repair machinery, or carcinogenic exposures; each mutagenic process leaves a characteristic mutational signature. A key challenge is understanding the interactions between signatures, particularly as DNA repair deficiencies often modify the...

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PMID: 34375586
DOI: 10.1016/j.cels.2021.07.004

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