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MUSICiAn: genome-wide identification of genes involved in DNA repair via control-free mutational spectra analysis.

NAR genomics and bioinformatics - 1 Mar 2026

Seale Colm, Barazas Marco, van Schendel Robin, Tijsterman Marcel, Gonçalves Joana P

Abstract excerpt

Understanding DNA double-strand break (DSB) repair is crucial for the development of targeted anticancer therapies, yet the roles of many genes remain unclear. Recent studies show that disruption of known DSB repair genes can alter the sequence-specific distribution of mutations arising after DSB repair, suggesting that genome-wide perturbation screens could be leveraged to identify new DSB genes leading to...

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PMID: 41524026
DOI: 10.1093/nargab/lqaf202
PMCID: PMC12783044

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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