Article

In-depth characterization of the cisplatin mutational signature in human cell lines and in esophageal and liver tumors

2017-09-17

Abstract excerpt

<h4>Background and aims</h4> Cisplatin reacts with DNA, and thereby likely generates a characteristic pattern of somatic mutations, called a mutational signature. Despite widespread use of cisplatin in cancer treatment and its role in contributing to secondary malignancies, its mutational signature has not been delineated. We hypothesize that cisplatin’s mutational signature can serve as a biomarker to identify c...

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Literature Corpus work: b2b551d9-ddd7-5edc-990f-396c66fdee68
DOI: 10.1101/189233

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