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Article

Investigating the origins of the mutational signatures in cancer.

Nucleic acids research - 7 Jan 2025

Boysen Gunnar, Alexandrov Ludmil B, Rahbari Raheleh, Nookaew Intawat, Ussery Dave, Chao Mu-Rong, Hu Chiung-Wen, Cooke Marcus S

Abstract excerpt

Most of the risk factors associated with chronic and complex diseases, such as cancer, stem from exogenous and endogenous exposures experienced throughout an individual's life, collectively known as the exposome. These exposures can modify DNA, which can subsequently lead to the somatic mutations found in all normal and tumor tissues. Understanding the precise origins of specific somatic mutations has been...

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PMID: 39778866
DOI: 10.1093/nar/gkae1303
PMCID: PMC11707540

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