Article

Drug-Target Mendelian Randomization and Imaging Mediation Analyses Reveal Therapeutic Targets and Causal Mechanisms for Cardiomyopathies

2026-04-22

Abstract excerpt

<h4>Background</h4> Hypertrophic (HCM) and dilated (DCM) cardiomyopathy constitute the principal phenotypes of primary cardiomyopathy, yet both lack sufficient therapeutic options. Integrating genetic insights with detailed cardiac phenotyping offers a promising strategy to prioritize targets and elucidate their mechanisms of action. <h4>Methods</h4> We conducted an three-stage analysis. First, drug-target Mende...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8459db67-6a24-50b1-ac28-a9c7d045e68f
DOI: 10.64898/2026.04.20.26351344

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Drug-Target Mendelian Randomization and Imaging Mediation Analyses Reveal Therapeutic Targets and Causal Mechanisms for CardiomyopathiesDOI 10.64898/2026.04.20.26351344Read

Potential Risk Factors and Therapeutic Targets for Dilated Cardiomyopathy Identified Through Mendelian Randomization Analysis.Semantic proximity Read

Large-scale Mendelian randomization identifies novel pathways as therapeutic targets for heart failure with reduced ejection fraction and with preserved ejection fractionSemantic proximity Read

Genome-wide association study reveals mechanisms underlying dilated cardiomyopathy and myocardial resilience.Semantic proximity Read

Leveraging the shared and opposing genetic mechanisms in the heritable cardiomyopathiesSemantic proximity Read

Multiomics Mendelian Randomization of GWAS, eQTL, and pQTL Combined With Drug Analysis to Predict Drug Targets in Myocardial Infarction.Semantic proximity Read

Genetic evidence prioritizes circulating proteins for heart failure beyond shared BMI-related genetic liabilitySemantic proximity Read

Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effect.Semantic proximity Read

Pathophysiology of dilated cardiomyopathy: from mechanisms to precision medicine.Semantic proximity Read

Therapeutic Targets for Heart Failure Identified Using Proteomics and Mendelian Randomization.Semantic proximity Read

Putative functional genes in idiopathic dilated cardiomyopathy.Semantic proximity Read

Transcriptome- and proteome-wide Mendelian randomization to prioritize therapeutic targets for coronary heart diseaseSemantic proximity Read

Genome-wide association analysis and Mendelian randomization proteomics identify drug targets for heart failureSemantic proximity Read