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Article

Potential Risk Factors and Therapeutic Targets for Dilated Cardiomyopathy Identified Through Mendelian Randomization Analysis.

Journal of the American Heart Association - 6 Jan 2026

Wang Hui, Wang Yihui, Huang Dezhi, Jiang Xiao, Li Caiyun, Xia Xuting, Liu Guichun, Shi Jianchen, Li Xinhui

Abstract excerpt

BACKGROUND: Dilated cardiomyopathy (DCM) is a severe form of cardiomyopathy. The study aims to investigate the impact of metabolic and lifestyle factors on DCM and to identify new potential therapeutic targets. METHODS: Both bidirectional Mendelian randomization (MR) and Bayesian colocalization were performed based on summary data from large-scale, genome-wide association studies and the FinnGen project. Single...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41467369
DOI: 10.1161/JAHA.124.038088
PMCID: PMC12909039

Genes

TGM2
CNTFR
DNAJB12
ETFA
GOLGB1
SEMA7A
SLC9B1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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