Article
Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effect.
Nature genetics - 1 Feb 2021
Tadros Rafik, Francis Catherine, Xu Xiao, Vermeer Alexa M C, Harper Andrew R, Huurman Roy, Kelu Bisabu Ken, Walsh Roddy, Hoorntje Edgar T, Te Rijdt Wouter P, Buchan Rachel J, van Velzen Hannah G, van Slegtenhorst Marjon A, Vermeulen Jentien M, Offerhaus Joost Allard, Bai Wenjia, de Marvao Antonio, Lahrouchi Najim, Beekman Leander, Karper Jacco C, Veldink Jan H, Kayvanpour Elham, Pantazis Antonis, Baksi A John, Whiffin Nicola, Mazzarotto Francesco, Sloane Geraldine, Suzuki Hideaki, Schneider-Luftman Deborah, Elliott Paul, Richard Pascale, Ader Flavie, Villard Eric, Lichtner Peter, Meitinger Thomas, Tanck Michael W T, van Tintelen J Peter, Thain Andrew, McCarty David, Hegele Robert A, Roberts Jason D, Amyot Julie, Dubé Marie-Pierre, Cadrin-Tourigny Julia, Giraldeau Geneviève, L'Allier Philippe L, Garceau Patrick, Tardif Jean-Claude, Boekholdt S Matthijs, Lumbers R Thomas, Asselbergs Folkert W, Barton Paul J R, Cook Stuart A, Prasad Sanjay K, O'Regan Declan P, van der Velden Jolanda, Verweij Karin J H, Talajic Mario, Lettre Guillaume, Pinto Yigal M, Meder Benjamin, Charron Philippe, de Boer Rudolf A, Christiaans Imke, Michels Michelle, Wilde Arthur A M, Watkins Hugh, Matthews Paul M, Ware James S, Bezzina Connie R
Abstract excerpt
The heart muscle diseases hypertrophic (HCM) and dilated (DCM) cardiomyopathies are leading causes of sudden death and heart failure in young, otherwise healthy, individuals. We conducted genome-wide association studies and multi-trait analyses in HCM (1,733 cases), DCM (5,521 cases) and nine left ventricular (LV) traits (19,260 UK Biobank participants with structurally normal hearts). We identified 16 loci...
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