Article

Large-scale Mendelian randomization identifies novel pathways as therapeutic targets for heart failure with reduced ejection fraction and with preserved ejection fraction

2024-03-24

Abstract excerpt

<h4>ABSTRACT</h4> We used expression quantitative trait loci (eQTLs) and protein quantitative trait loci (pQTLs) to conduct genome-wide Mendelian randomization (MR) using 27,799 cases of heart failure (HF) with reduced ejection fraction (HFrEF), 27,579 cases of HF with preserved ejection fraction (HFpEF), and 367,267 control individuals from the Million Veteran Program (MVP). We identified 70 HFrEF and 10 HFpEF ge...

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Literature Corpus work: 381288ff-b902-52bc-adce-91a04053cbc8
DOI: 10.1101/2024.03.22.24304728

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