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Article

Genome-wide association analysis and Mendelian randomization proteomics identify drug targets for heart failure

2022-04-18

Abstract excerpt

We conduct a large-scale meta-analysis of heart failure genome-wide association studies (GWAS) consisting of over 90,000 heart failure cases and more than 1 million control individuals of European ancestry to uncover novel genetic determinants for heart failure. Using the GWAS results and blood protein quantitative loci, we perform Mendelian randomization and colocalization analyses on human proteins to provide pu...

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Identifiers and source

Literature Corpus work
30d8d81c-17af-5b81-a885-18609b2377a7
DOI
10.1101/2022.04.14.22273877
Open publication

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Genome-wide association analysis and Mendelian randomization proteomics identify drug targets for heart failureDOI 10.1101/2022.04.14.22273877
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