Article
Genome-wide association study reveals mechanisms underlying dilated cardiomyopathy and myocardial resilience.
Nature genetics - 1 Dec 2024
Jurgens Sean J, Rämö Joel T, Kramarenko Daria R, Wijdeveld Leonoor F J M, Haas Jan, Chaffin Mark D, Garnier Sophie, Gaziano Liam, Weng Lu-Chen, Lipov Alex, Zheng Sean L, Henry Albert, Huffman Jennifer E, Challa Saketh, Rühle Frank, Verdugo Carmen Diaz, Krijger Juárez Christian, Kany Shinwan, van Orsouw Constance A, Biddinger Kiran, Poel Edwin, Elliott Amanda L, Wang Xin, Francis Catherine, Ruan Richard, Koyama Satoshi, Beekman Leander, Zimmerman Dominic S, Deleuze Jean-François, Villard Eric, Trégouët David-Alexandre, Isnard Richard, Boomsma Dorret I, de Geus Eco J C, Tadros Rafik, Pinto Yigal M, Wilde Arthur A M, Hottenga Jouke-Jan, Sinisalo Juha, Niiranen Teemu, Walsh Roddy, Schmidt Amand F, Choi Seung Hoan, Chang Kyong-Mi, Tsao Philip S, Matthews Paul M, Ware James S, Lumbers R Thomas, van der Crabben Saskia, Laukkanen Jari, Palotie Aarno, Amin Ahmad S, Charron Philippe, Meder Benjamin, Ellinor Patrick T, Daly Mark, Aragam Krishna G, Bezzina Connie R
Abstract excerpt
Dilated cardiomyopathy (DCM) is a heart muscle disease that represents an important cause of morbidity and mortality, yet causal mechanisms remain largely elusive. Here, we perform a large-scale genome-wide association study and multitrait analysis for DCM using 9,365 cases and 946,368 controls. We identify 70 genome-wide significant loci, which show broad replication in independent samples and map to 63...
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