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Genetic evidence prioritizes circulating proteins for heart failure beyond shared BMI-related genetic liability

2026-06-22

Abstract excerpt

<h4>Background</h4> Heart failure (HF) and body mass index (BMI) share substantial genetic architecture, which may lead genetically informed target discovery to preferentially identify adiposity-related pathways. We sought to identify circulating proteins associated with HF beyond this shared genetic component. <h4>Methods</h4> We applied GWAS-by-subtraction to overall HF, nonischemic HF, and nonischemic HF with...

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Literature Corpus work
028c66b7-43f4-5592-8478-891ce00cf057
DOI
10.64898/2026.06.19.26356109
Open publication

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Genetic evidence prioritizes circulating proteins for heart failure beyond shared BMI-related genetic liabilityDOI 10.64898/2026.06.19.26356109
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