Article
Putative functional genes in idiopathic dilated cardiomyopathy.
Scientific reports - 8 Jan 2018
Nair Nishanth Ulhas, Das Avinash, Amit Uri, Robinson Welles, Park Seung Gu, Basu Mahashweta, Lugo Alex, Leor Jonathan, Ruppin Eytan, Hannenhalli Sridhar
Abstract excerpt
Idiopathic dilated cardiomyopathy (DCM) is a complex disorder with a genetic and an environmental component involving multiple genes, many of which are yet to be discovered. We integrate genetic, epigenetic, transcriptomic, phenotypic, and evolutionary features into a method - Hridaya, to infer putative functional genes underlying DCM in a genome-wide fashion, using 213 human heart genomes and transcriptomes....
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