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Article

Multiomics Mendelian Randomization of GWAS, eQTL, and pQTL Combined With Drug Analysis to Predict Drug Targets in Myocardial Infarction.

Journal of cardiovascular pharmacology and therapeutics - 1 Jan 2026

Yuan Didi, Hu Lian, Huang Yanqing, Tang Haotian, Ma Yuchen, Hu Sai, Liu Junwen

Abstract excerpt

Despite significant advances in the management of myocardial infarction (MI), therapeutic options targeting upstream pathogenic mechanisms remain scarce. This study introduces a novel multiomics-to-drug discovery framework to identify and validate causal therapeutic targets for MI. We conducted a systematic two-sample Mendelian randomization (MR) analysis integrating expression quantitative trait loci (eQTL) and...

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Identifiers

PMID: 41989152
DOI: 10.1177/10742484261440344

Genes

BMP1
ALDH2
APOB
FABP2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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