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Article

Transcriptome- and proteome-wide Mendelian randomization to prioritize therapeutic targets for coronary heart disease

2024-06-28

Abstract excerpt

Despite widespread use of drugs targeting traditional cardiovascular risk factors such as lipids and blood pressure, a high burden of coronary heart disease (CHD) remains, hence novel therapeutics are needed for people who harbor residual risk. Using transcriptomic and proteomic data to instrument 15,527 genes or proteins, we conducted systematic cis- Mendelian randomization (MR) and conditional colocalization an...

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Literature Corpus work
a14c4400-1004-562d-8e2a-689c35e6989f
DOI
10.1101/2024.06.27.24309406
Open publication

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Transcriptome- and proteome-wide Mendelian randomization to prioritize therapeutic targets for coronary heart diseaseDOI 10.1101/2024.06.27.24309406
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