Article

AI-assisted protein design to rapidly convert antibody sequences to intrabodies targeting diverse peptides and histone modifications

2025-02-08

Abstract excerpt

<h4>ABSTRACT</h4> Intrabodies are engineered antibodies that function inside living cells, enabling therapeutic, diagnostic, and imaging applications. While powerful, their development has been hindered by challenges associated with their folding, solubility, and stability in the reduced intracellular environment. Here, we present an AI-driven pipeline integrating AlphaFold2, ProteinMPNN, and live-cell screening...

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Literature Corpus work: 8447953e-3e4e-5ecf-a5be-08bc53e88fd8
DOI: 10.1101/2025.02.06.636921

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