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Article

Evolution of nanobodies specific for BCL11A

10 Jan 2023

Abstract excerpt

Transcription factors (TFs) control numerous genes that are directly relevant to many human disorders. However, developing specific reagents targeting TFs within intact cells is challenging due to the presence of highly disordered regions within these proteins. Intracellular antibodies offer opportunities to probe protein function and validate therapeutic targets. Here, we describe the optimization of nanobodies...

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PMID: 36626555
DOI: 10.1073/pnas.2218959120

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