Article

An AI-driven approach for nanobody affinity maturation

2025-11-12

Abstract excerpt

B7-H3 (CD276), an immunoregulatory checkpoint molecule overexpressed in numerous cancers, is a promising therapeutic target. Nanobodies possess unique advantages for targeting B7-H3, such as small size, high stability, and the ability to bind cryptic epitopes. However, the rational affinity maturation of these nanobodies is challenging, especially in the absence of detailed structural data on antigen-antibody inte...

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Literature Corpus work: 8298c99c-e008-568a-91f5-d5d7bd5eec99
DOI: 10.1101/2025.11.11.687768

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