Article

Reliable repurposing of antibody interactome inside the cell

2025-11-16

Abstract excerpt

In biology proximity is paramount and eighty-five percent of the human proteome has at least one documented interacting monoclonal antibody. These molecules penetrate the cytoplasm poorly and are very often non-functional within the cell. Sequence analysis of 10 6 antibody variable domains alongside the cytoplasmic human proteome shows charge and isoelectric point are characteristics ill adapted to intracellular...

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Literature Corpus work: a389d787-fd00-5e1d-b27c-e78e02a6952d
DOI: 10.1101/2025.11.16.688718

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