Article

AI-Guided Precision in Antibody Humanization: Structural Modeling to Minimize Immunogenicity and Preserve Efficacy

2025-03-13

Abstract excerpt

Antibody humanization is an essential part of converting animal-derived antibodies into clinical candidates however conventional CDR grafting techniques often faces challenges, especially when essential antigen-binding sites extend beyond CDR regions. Additionally, the CDR grafting process tends to retain undesired non-human elements within the CDR regions. In this study, we overcame these challenges by using our...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a096bca9-64c5-5cf1-8abc-3e948eece363
DOI: 10.1101/2025.03.09.641110

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

AI-Guided Precision in Antibody Humanization: Structural Modeling to Minimize Immunogenicity and Preserve EfficacyDOI 10.1101/2025.03.09.641110Read

Antibody humanization methods – a review and updateSemantic proximity Read

Reliable energy-based antibody humanization and stabilizationSemantic proximity Read

Antibody humanization by CDR grafting.Semantic proximity Read

Structure guided homology model based design and engineering of mouse antibodies for humanizationSemantic proximity Read

Humatch - fast, gene-specific joint humanisation of antibody heavy and light chainsSemantic proximity Read

Sagacious Epitope Selection for Vaccines, and Both Antibody-Based Therapeutics and Diagnostics: Tips From Virology and Oncology<strong> </strong>Semantic proximity Read

Structure-guided design of antibody CDRs to reduce their reactivity to treatment-emergent anti-drug antibodies.Semantic proximity Read

Augmented Binary Substitution: Single-pass CDR germ-lining and stabilization of therapeutic antibodies.Semantic proximity Read

AI-assisted protein design to rapidly convert antibody sequences to intrabodies targeting diverse peptides and histone modificationsSemantic proximity Read

A molecular immunology approach to antibody humanization and functional optimizationSemantic proximity Read

Molecular Insights into Ultra-Humanisation of mAbs: Crystal Structure of Ultra-Humanised anti-pTau Fab Reveals Unmodified Binding InteractionsSemantic proximity Read

Better antibodies engineered with a GLIMPSE of human dataSemantic proximity Read