AbNatiV: VQ-VAE-based assessment of antibody and nanobody nativeness for hit selection, humanisation, and engineering

Abstract excerpt

Monoclonal antibodies have emerged as key therapeutics, and nanobodies are rapidly gaining momentum following the approval of the first nanobody drug in 2019. Nonetheless, the development of these biologics as therapeutics remains a challenge. Despite the availability of established in vitro directed evolution technologies that are relatively fast and cheap to deploy, the gold standard for generating therapeutic a...

Topics

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• Biosimilars and Bioanalytical Methods
• Chronic Lymphocytic Leukemia Research
• Glycosylation and Glycoproteins Research
• Monoclonal and Polyclonal Antibodies Research
• Protein purification and stability
• Receptor Mechanisms and Signaling
• vaccines and immunoinformatics approaches
• Viral Infectious Diseases and Gene Expression in Insects

Identifiers and source

Literature Corpus work

4fad5ba9-fd79-512d-8513-f91234154160

DOI

10.1101/2023.04.28.538712