Article

An <i>in silico</i> method to assess antibody fragment polyreactivity

2022-01-13

Abstract excerpt

<h4>ABSTRACT</h4> Antibodies are essential biological research tools and important therapeutic agents, but some exhibit non-specific binding to off-target proteins and other biomolecules. Such polyreactive antibodies compromise screening pipelines, lead to incorrect and irreproducible experimental results, and are generally intractable for clinical development. We designed a set of experiments using a diverse naï...

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Literature Corpus work: 5dc12105-3ee0-5403-9d6f-1cf8b4238d01
DOI: 10.1101/2022.01.12.476085

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