Article

Impact of Translocator Protein 18 kDa (TSPO)-Deficiency on Mitochondrial Function and Inflammatory State of Human C20 Microglia Cells

2023-02-09

Abstract excerpt

Microglia are the resident immune cells of the central nervous system. Upon stimulus presentation microglia polarize from a resting to an activated state. Microglial translocator protein 18 kDa (TSPO) is considered as a marker of inflammation. Here, we characterized the role of TSPO by investigating the impact of TSPO deficiency on human microglia. We used TSPO knockout (TSPO-/-) variants of the human C20 microgli...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 832f6b7e-bb75-5041-bc0b-7ea6c25a781d
DOI: 10.20944/preprints202302.0161.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Impact of Translocator Protein 18 kDa (TSPO)-Deficiency on Mitochondrial Function and Inflammatory State of Human C20 Microglia CellsDOI 10.20944/preprints202302.0161.v1Read

A comprehensive functional investigation of the human translocator protein 18 kDa (TSPO) in a novel human neuronal cell knockout model: from molecule to depressionSemantic proximity Read

Mitochondria drive microglial NRLP3 inflammasome activation via TSPOSemantic proximity Read

Translocator protein (18 kDa) regulates the microglial phenotype in Parkinson's disease through P47.Semantic proximity Read

History of Tspo deletion and induction in vivo: Phenotypic outcomes under physiological and pathological situations.Semantic proximity Read

The microglial translocator protein (TSPO) in Alzheimer's disease reflects a phagocytic phenotype.Semantic proximity Read

The Role of Translocator Protein TSPO in Hallmarks of GlioblastomaSemantic proximity Read

Differential mitochondrial protein interaction profile between human translocator protein and its <i>A147T</i> polymorphism variantSemantic proximity Read

The human microglial surveillant phenotype is preserved by de novo neurosteroidogenesis through the control of cholesterol homeostasis: Crucial role of 18 kDa Translocator Protein.Semantic proximity Read

Targeting mitochondrial 18 kDa translocator protein (TSPO) regulates macrophage cholesterol efflux and lipid phenotype.Semantic proximity Read

TSPO contributes to neuropathology and cognitive deficits in Alzheimer’s diseaseSemantic proximity Read

Amelioration of signalling deficits underlying metabolic shortfall in TREM2 <sup>R47H</sup> human iPSC-derived microgliaSemantic proximity Read

Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseasesSemantic proximity Read