Article

Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases

2022-05-11

Abstract excerpt

Microglial activation plays central roles in neuro-inflammatory and neurodegenerative diseases. Positron emission tomography (PET) targeting 18kDa Translocator Protein (TSPO) is widely used for localising inflammation in vivo , but its quantitative interpretation remains uncertain. We show that TSPO expression increases in activated microglia in mouse brain disease models but does not change in a non-human primat...

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Literature Corpus work: fc0c809e-613c-5096-896f-8bc5ba7f2ab7
DOI: 10.1101/2022.05.11.491453

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