Article
The human microglial surveillant phenotype is preserved by de novo neurosteroidogenesis through the control of cholesterol homeostasis: Crucial role of 18 kDa Translocator Protein.
Biochimica et biophysica acta. Molecular basis of disease - 1 Aug 2023
Angeloni Elisa, Germelli Lorenzo, Marchetti Laura, Da Pozzo Eleonora, Tremolanti Chiara, Wetzel Christian H, Baglini Emma, Taliani Sabrina, Da Settimo Federico, Martini Claudia, Costa Barbara
Abstract excerpt
Neurodegenerative disease-associated microglia commonly exhibit harmful cholesterol accumulation that impairs their ability to resolve the neuroinflammatory response, contributing to disease onset and progression. Neurosteroids, whose levels have been often found significantly altered in brain diseases, are the most potent endogenous anti-inflammatory molecules exerting beneficial effects on activities of brain...
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