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Differential mitochondrial protein interaction profile between human translocator protein and its <i>A147T</i> polymorphism variant

2021-07-23

Abstract excerpt

The translocator protein (TSPO) has been implicated in mitochondrial transmembrane cholesterol transport, brain inflammation, and other mitochondrial functions. It is upregulated in glial cells during neuroinflammation in Alzheimer’s disease. High affinity TSPO imaging radioligands are utilized to visualize neuroinflammation. However, this is hampered by the common A147T polymorphism which compromises ligand bindi...

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Literature Corpus work
f6978177-c0f0-5167-9502-41aa51196f8b
DOI
10.1101/2021.07.23.453531
Open publication

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Differential mitochondrial protein interaction profile between human translocator protein and its <i>A147T</i> polymorphism variantDOI 10.1101/2021.07.23.453531
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