Article

TSPO contributes to neuropathology and cognitive deficits in Alzheimer’s disease

2025-07-02

Abstract excerpt

<title>Abstract</title> <p>The 18kDa translocator protein (TSPO) is increased in neurodegenerative diseases. In Alzheimer's disease (AD) animal models, TSPO’s upregulation is detected first in astrocytes, then in microglia. However, the role of TSPO in the pathophysiology and symptoms characteristic of the disease remains unknown. In the human <italic>postmortem</italic> hippocampus, we show here that TSPO correl...

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Literature Corpus work: 6d59503b-d6ee-5026-83e3-e41a5df7c512
DOI: 10.21203/rs.3.rs-7008246/v1

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