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Article

The microglial translocator protein (TSPO) in Alzheimer's disease reflects a phagocytic phenotype.

Acta neuropathologica - 14 Nov 2024

Garland Emma F, Antony Henrike, Kulagowska Laura, Scott Thomas, Rogien Charlotte, Bottlaender Michel, Nicoll James A R, Boche Delphine

Abstract excerpt

Translocator protein (TSPO) is a mitochondrial protein expressed by microglia, ligands for which are used as a marker of neuroinflammation in PET studies of Alzheimer's disease (AD). We previously showed increasing TSPO load in the cerebral cortex with AD progression, consistent with TSPO PET scan findings. Here, we aim to characterise the microglial phenotype associated with TSPO expression to aid interpretation...

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Identifiers

PMID: 39540994
DOI: 10.1007/s00401-024-02822-x
PMCID: PMC11564344

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