Article

Amelioration of signalling deficits underlying metabolic shortfall in TREM2 <sup>R47H</sup> human iPSC-derived microglia

2024-02-12

Abstract excerpt

Classic immunometabolic switching from oxidative phosphorylation (OXPHOS) to glycolysis occurs in myeloid cells such as microglia when encountering pathogenic insults. We previously showed that patient iPSC-derived microglia (iPS-Mg) harbouring the Alzheimer’s disease (AD) TREM2 R47H hypomorph display deficits in the ability to metabolically switch from OXPHOS to glycolysis, with both reduced mitochondrial maxima...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 270101b9-aed6-5a97-b00f-6215b8380c17
DOI: 10.1101/2024.02.12.579896

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Amelioration of signalling deficits underlying metabolic shortfall in TREM2 <sup>R47H</sup> human iPSC-derived microgliaDOI 10.1101/2024.02.12.579896Read

A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC--derived microgliaSemantic proximity Read

Microglial signalling pathway deficits associated with the R47H TREM2 variant linked to AD indicate inability to activate inflammasomeSemantic proximity Read

C9orf72 Repeat Expansion Induces Metabolic Dysfunction in Human iPSC-Derived Microglia and Modulates Glial–Neuronal CrosstalkSemantic proximity Read

Microglia reprogram metabolic profiles for phenotype and function changes in central nervous system.Semantic proximity Read

APOE genotype-dependent differences in human astrocytic energy metabolismSemantic proximity Read

TREM2 fuels the anabolic adaptation required for microglial resilience in Alzheimer’s diseaseSemantic proximity Read

Up-regulated succinylation modifications induce a senescence phenotype in microglia by altering mitochondrial energy metabolism.Semantic proximity Read

MS-driven metabolic alterations are recapitulated in iPSC-derived astrocytesSemantic proximity Read

APOE genotype-dependent differences in human astrocytic energy metabolismSemantic proximity Read

Deficits in mitochondrial function and glucose metabolism seen in sporadic and familial Alzheimer’s disease derived Astrocytes are ameliorated by increasing hexokinase 1 expressionSemantic proximity Read

TREM1 disrupts myeloid bioenergetics and cognitive function in aging and Alzheimer’s disease modelsSemantic proximity Read

Single-Cell RNA Sequencing Analysis of Microglia Dissected the Energy Metabolism and Revealed Potential Biomarkers in Amyotrophic Lateral SclerosisSemantic proximity Read