Article

Mitochondria drive microglial NRLP3 inflammasome activation via TSPO

2024-03-18

Abstract excerpt

Uncontrolled microglial response is core to neuroinflammatory brain diseases. The correlation between the mitochondrial protein TSPO and inflammation has so far failed to explain whether TSPO positively or negatively regulates microglial function. The recent evidence on the species specificity of TSPO in microglia demands a deeper understanding of the protein biology in these brain-resident macrophages. To this en...

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Identifiers and source

Literature Corpus work: 7880474e-fcf2-5c44-9a1d-318b751ffc13
DOI: 10.1101/2024.03.18.585507

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