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Direct visualization of MCM helicase activation and replisome coupling in situ

2026-08-24

Abstract excerpt

Deciphering the spatial organization of molecular machines that copy the genome remains a fundamental challenge in biology. Essential for eukaryotic DNA replication, Mini-Chromosome Maintenance (MCM2-7) helicases are loaded during G1 as double hexamers (DHs) to license replication origins. Upon activation in S phase, each DH is thought to split into two single hexamers (SHs) that form the active CMG helicases and...

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Literature Corpus work
fa136404-3e80-55eb-a12e-4d466e74d299
DOI
10.64898/2026.08.21.746258
Open publication

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Direct visualization of MCM helicase activation and replisome coupling in situDOI 10.64898/2026.08.21.746258
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