Article

ChromoTrace: Computational Reconstruction of 3D Chromosome Configurations for Super-Resolution Microscopy

2017-03-09

Abstract excerpt

The 3D structure of chromatin plays a key role in genome function, including gene expression, DNA replication, chromosome segregation, and DNA repair. Furthermore the location of genomic loci within the nucleus, especially relative to each other and nuclear structures such as the nuclear envelope and nuclear bodies strongly correlates with aspects of function such as gene expression. Therefore, determining the 3D...

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Literature Corpus work: 827ea3ec-9b33-51f7-823f-7f0f4b98f9d6
DOI: 10.1101/115436

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