Article

Imputation-free reconstructions of three-dimensional chromosome architectures in human diploid single-cells using allele-specified contacts

2021-10-04

Abstract excerpt

The sparseness of chromosomal contact information and the presence of homologous chromosomes with very similar nucleotide sequences make Hi-C analysis difficult. We propose a new algorithm using allele-specific single-nucleotide variations (SNVs) to reconstruct the three-dimensional (3D) chromosomal architectures from the Hi-C dataset of single diploid cells. Our algorithm has a function to discriminate SNVs speci...

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Literature Corpus work: b2ccda10-f39c-5246-9ee4-a39abd481aa5
DOI: 10.1101/2021.10.04.462972

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