Article

Single cell RNA sequencing reveals immunomodulatory effects of stem cell factor and granulocyte colony-stimulating factor treatment in the brains of aged APP/PS1 mice

2024-05-09

Abstract excerpt

Alzheimer’s disease (AD) leads to progressive neurodegeneration and dementia. AD primarily affects older adults with neuropathological changes including amyloid-beta (Aβ) deposition, neuroinflammation, and neurodegeneration. We have previously demonstrated that systemic treatment with combined stem cell factor (SCF) and granulocyte colony-stimulating factor (G-CSF) (SCF+G-CSF), reduces Aβ load, increases Aβ uptake...

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Literature Corpus work: 8252dfde-5677-551f-8c52-8e59c8c7b56f
DOI: 10.1101/2024.05.09.593359

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