Proliferating Microglia Exhibit Unique Transcriptional and Functional Alterations in Alzheimer’s Disease

Abstract excerpt

Proliferation of microglia represents a physiological process, which is accelerated in several neurodegenerative disorders including Alzheimer disease (AD). The effect of such neurodegeneration-associated microglial proliferation on function and disease progression remains unclear. Here, we show that proliferation results in profound alterations of cellular function by providing evidence that newly proliferated...

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