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Single-cell transcriptomics reveals colonic immune perturbations during amyloid-β driven Alzheimer’s disease in mice

2024-01-30

Abstract excerpt

The “gut-brain axis” is emerging as an important target in Alzheimer’s disease (AD). However, immunological mechanisms underlying this axis remain poorly understood. Using single-cell RNA sequencing of the colon immune compartment in the 5XFAD amyloid-β (Aβ) mouse model, we uncovered AD-associated changes in ribosomal activity, oxidative stress, and BCR/plasma cell activity. Strikingly, levels of colon CXCR4 + an...

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Literature Corpus work
728cf94f-b3fa-5f2b-85b0-220ceec3ba7b
DOI
10.1101/2024.01.27.573841
Open publication

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Single-cell transcriptomics reveals colonic immune perturbations during amyloid-β driven Alzheimer’s disease in miceDOI 10.1101/2024.01.27.573841
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