Article

Transcriptomic analysis reveals new reparative mechanisms of SCF+G-CSF-reduced neuropathology in aged APP/PS1 mice

2025-05-15

Abstract excerpt

Alzheimer’s Disease (AD) is a neurodegenerative disease characterized by amyloid plaque deposition, tau hyperphosphorylation, neuroinflammation, and cognitive decline. Our previous studies showed that combined treatment with stem cell factor (SCF) and granulocyte colony-stimulating factor (G-CSF) reduces AD pathology in APP/PS1 mice. This study aimed to explore the molecular mechanism underlying SCF+G-CSF’s therap...

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Literature Corpus work: 14530e83-349f-5b8e-ac03-cb4cc5b26b15
DOI: 10.1101/2025.05.10.653288

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