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Crosstalk between RNA m <sup>6</sup> A and DNA methylation regulates transposable element chromatin activation and cell fate in human pluripotent stem cells

2022-09-12

Abstract excerpt

<h4>ABSTRACT</h4> Transposable elements (TEs) are parasitic DNA sequences accounting for over half of the human genome. Tight control of the repression and activation states of TEs is critical for genome integrity, development, immunity, and diseases, including cancer. However, precisely how this regulation is achieved remains unclear. To address this question, we develop a targeted proteomic proximity labeling a...

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Literature Corpus work
75015f99-1cde-5779-a3a2-527bfd2943e5
DOI
10.1101/2022.09.08.507172
Open publication

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Crosstalk between RNA m <sup>6</sup> A and DNA methylation regulates transposable element chromatin activation and cell fate in human pluripotent stem cellsDOI 10.1101/2022.09.08.507172
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