Article

Neuronal ROS-Induced Glial Lipid Droplet Formation is Altered by Loss of Alzheimer’s Disease-associated Genes

2021-03-04

Abstract excerpt

<h4>Summary</h4> A growing list of Alzheimer’s disease (AD) genetic risk factors is being identified, but the contribution of these genetic mutations to disease remains largely unknown. Accumulating data support a role of lipid dysregulation and excessive ROS in the etiology of AD. Here, we identified cell-specific roles for eight AD risk-associated genes in ROS-induced glial lipid droplet (LD) formation. We demo...

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Literature Corpus work: 81f8a420-d6af-5314-8174-c13e201f8dc2
DOI: 10.1101/2021.03.03.433580

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