Article

Disrupted Lipid Homeostasis as a Pathogenic Mechanism in <i>ABCA7</i> -Associated Alzheimer’s Disease Risk

2025-09-07

Abstract excerpt

<h4>INTRODUCTION</h4> ABCA7 ( ATP-binding cassette sub-family A member 7 ) encodes a lipid transporter linked to Alzheimer’s disease (AD). While common variants confer modest risk in Europeans, a 44-base pair deletion (rs142076058; p.Arg578Alafs) is a strong risk factor in African Americans (AA). Despite this, the biological consequences of this ancestry-specific variant are not well understood. <h4>METHODS</h4...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 285ad349-684c-553e-9707-294837c12b63
DOI: 10.1101/2025.09.03.673792

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Disrupted Lipid Homeostasis as a Pathogenic Mechanism in <i>ABCA7</i> -Associated Alzheimer’s Disease RiskDOI 10.1101/2025.09.03.673792Read

The ABC's of Alzheimer risk gene ABCA7.Semantic proximity Read

ABCA7 Loss-of-Function Variants Impact Phosphatidylcholine Metabolism in the Human BrainSemantic proximity Read

The role of ABCA7 in Alzheimer’s disease: evidence from genomics, transcriptomics and methylomicsSemantic proximity Read

ABCA7 and Pathogenic Pathways of Alzheimer’s DiseaseSemantic proximity Read

<i>ABCA7</i> loss-of-function variants, expression, and neurologic disease riskSemantic proximity Read

<i>ABCA7</i> frameshift deletion associated with Alzheimer disease in African AmericansSemantic proximity Read

ABCA7 Deficiency Accelerates Amyloid-β Generation and Alzheimer's Neuronal Pathology.Semantic proximity Read

Role of ABCA7 in Human Health and in Alzheimer's Disease.Semantic proximity Read

ABCA7 in Alzheimer's Disease.Semantic proximity Read

ABCA7-Associated Clinical Features and Molecular Mechanisms in Alzheimer’s DiseaseSemantic proximity Read

The Alzheimer's disease GWAS risk alleles in the ABCA7 promoter and 5' region reduce ABCA7 expression.Semantic proximity Read

Genetic Variations in ABCA7 Can Increase Secreted Levels of Amyloid-β40 and Amyloid-β42 Peptides and ABCA7 Transcription in Cell Culture Models.Semantic proximity Read