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Depletion of the AD risk gene <i>SORL1</i> selectively impairs neuronal endosomal traffic independent of amyloidogenic APP processing

2020-01-06

Abstract excerpt

<h4>Summary</h4> The SORL1 gene encodes for the protein SorLA, a sorting receptor involved in retromer-related endosomal traffic. Many SORL1 genetic variants increase Alzheimer’s disease (AD) risk, and rare loss-of-function truncation mutations have been found to be causal of late-onset AD. SORL1 is expressed in neurons and glia of the central nervous system and loss of SORL1 has been reported in AD tissue. T...

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Literature Corpus work
7a7930ae-681a-5383-b585-48deee777270
DOI
10.1101/2020.01.06.896670
Open publication

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Depletion of the AD risk gene <i>SORL1</i> selectively impairs neuronal endosomal traffic independent of amyloidogenic APP processingDOI 10.1101/2020.01.06.896670
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