Article

Contributions of genetic variation in astrocytes to cell and molecular mechanisms of risk and resilience to late onset Alzheimer’s disease

2024-07-31

Abstract excerpt

Reactive astrocytes are associated with Alzheimer’s disease (AD), and several AD genetic risk variants are associated with genes highly expressed in astrocytes. However, the contribution of genetic risk within astrocytes to cellular processes relevant to the pathogenesis of AD remains ill-defined. Here we present a resource for studying AD genetic risk in astrocytes using a large collection of induced pluripotent...

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Literature Corpus work: dfdce2c9-5acc-561b-860f-c838f9d8d39f
DOI: 10.1101/2024.07.31.605928

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