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Glial Draper Rescues Aβ Toxicity in aDrosophilaModel of Alzheimer's Disease

6 Nov 2017

Abstract excerpt

Pathological hallmarks of Alzheimer's disease (AD) include amyloid-β (Aβ) plaques, neurofibrillary tangles, and reactive gliosis. Glial cells offer protection against AD by engulfing extracellular Aβ peptides, but the repertoire of molecules required for glial recognition and destruction of Aβ are still unclear. Here, we show that the highly conserved glial engulfment receptor Draper/MEGF10 provides...

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PMID: 29109235
DOI: 10.1523/jneurosci.0862-17.2017

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