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Alzheimer’s disease protective allele of <i>Clusterin</i> modulates neuronal excitability through lipid-droplet-mediated neuron-glia communication

2024-08-15

Abstract excerpt

<h4>Summary</h4> Genome-wide association studies (GWAS) of Alzheimer’s disease (AD) have identified a plethora of risk loci. However, the disease variants/genes and the underlying mechanisms remain largely unknown. For a strong AD-associated locus near Clusterin ( CLU ), we tied an AD protective allele to a role of neuronal CLU in promoting neuron excitability through lipid-mediated neuron-glia communication. W...

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Literature Corpus work
51ab97ae-5e89-5c49-b07a-d0321882d5ad
DOI
10.1101/2024.08.14.24312009
Open publication

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Alzheimer’s disease protective allele of <i>Clusterin</i> modulates neuronal excitability through lipid-droplet-mediated neuron-glia communicationDOI 10.1101/2024.08.14.24312009
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