Somatic targeted mutation profiling of colorectal cancer precursor lesions.

doi:10.1186/s12920-022-01294-w

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Article

Somatic targeted mutation profiling of colorectal cancer precursor lesions.

BMC medical genomics - 28 Jun 2022

Dos Santos Wellington, Dos Reis Mariana Bisarro, Porto Jun, de Carvalho Ana Carolina, Matsushita Marcus, Oliveira Gabriela, Syrjänen Kari, Reis Rui Manuel, Guimarães Denise Peixoto

Abstract excerpt

BACKGROUND: Most colorectal cancers (CRC) arise from precursor lesions. This study aimed to characterize the mutation profile of colorectal cancer precursor lesions in a Brazilian population. METHODS: In total, 90 formalin-fixed paraffin-embedded colorectal precursor lesions, including 67 adenomas, 7 sessile serrated lesions, and 16 hyperplastic polyps, were analyzed by next-generation sequencing using a panel of...

Topics

Adenoma
Colonic Polyps
Colorectal Neoplasms
Humans
Mutation
Proto-Oncogene Proteins B-raf
Proto-Oncogene Proteins p21(ras)

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Identifiers

PMID: 35761395
DOI: 10.1186/s12920-022-01294-w
PMCID: PMC9238170

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