Article
The landscape of somatic mutation in normal colorectal epithelial cells.
Nature - 1 Oct 2019
Lee-Six Henry, Olafsson Sigurgeir, Ellis Peter, Osborne Robert J, Sanders Mathijs A, Moore Luiza, Georgakopoulos Nikitas, Torrente Franco, Noorani Ayesha, Goddard Martin, Robinson Philip, Coorens Tim H H, O'Neill Laura, Alder Christopher, Wang Jingwei, Fitzgerald Rebecca C, Zilbauer Matthias, Coleman Nicholas, Saeb-Parsy Kourosh, Martincorena Inigo, Campbell Peter J, Stratton Michael R
Abstract excerpt
The colorectal adenoma-carcinoma sequence has provided a paradigmatic framework for understanding the successive somatic genetic changes and consequent clonal expansions that lead to cancer1. However, our understanding of the earliest phases of colorectal neoplastic changes-which may occur in morphologically normal tissue-is comparatively limited, as for most cancer types. Here we use whole-genome sequencing to...
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