Article

The landscape of somatic mutation in normal colorectal epithelial cells

2018-09-13

Abstract excerpt

The colorectal adenoma-carcinoma sequence has provided a paradigmatic framework for understanding the successive somatic genetic changes and consequent clonal expansions leading to cancer. As for most cancer types, however, understanding of the earliest phases of colorectal neoplastic change, which may occur in morphologically normal tissue, is comparatively limited because of the difficulty of detecting somatic m...

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Literature Corpus work: ef10dc98-09f1-508c-9666-dac08ff4a0d6
DOI: 10.1101/416800

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