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Article

New insights into the earliest stages of colorectal tumorigenesis.

Expert review of gastroenterology & hepatology - 1 Aug 2017

Sievers Chelsie K, Grady William M, Halberg Richard B, Pickhardt Perry J

Abstract excerpt

INTRODUCTION: Tumors in the large intestine have been postulated to arise via a stepwise accumulation of mutations, a process that takes up to 20 years. Recent advances in lineage tracing and DNA sequencing, however, are revealing new evolutionary models that better explain the vast amount of heterogeneity observed within and across colorectal tumors. Areas covered: A review of the literature supporting a novel...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Transformation, Neoplastic

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Source

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Identifiers

PMID: 28503955
DOI: 10.1080/17474124.2017.1330150
PMCID: PMC5859121

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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