Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The somatic mutation landscape of premalignant colorectal adenoma.

Gut - 1 Jul 2018

Lin Shu-Hong, Raju Gottumukkala S, Huff Chad, Ye Yuanqing, Gu Jian, Chen Jiun-Sheng, Hildebrandt Michelle A T, Liang Han, Menter David G, Morris Jeffery, Hawk Ernest, Stroehlein John R, Futreal Andrew, Kopetz Scott, Mishra Lopa, Wu Xifeng

Abstract excerpt

OBJECTIVE: There are few studies which characterised the molecular alterations in premalignant colorectal adenomas. Our major goal was to establish colorectal adenoma genome atlas and identify molecular markers of progression from colorectal adenoma to adenocarcinoma. DESIGN: Whole-exome sequencing and targeted sequencing were carried out in 149 adenoma samples and paired blood from patients with conventional...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma
Share to Adenoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cohort Studies

Share to Colorectal Neoplasms

Share to Exome Sequencing

Share to Genetic factors in colorectal cancer

Share to Mutation

Share to Precancerous Conditions

Source

Open in PubMed Open full text

Identifiers

PMID: 28607096
DOI: 10.1136/gutjnl-2016-313573
PMCID: PMC6031265

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The somatic mutation landscape of premalignant colorectal adenoma.PMID 28607096Read ↗

The landscape of somatic mutation in normal colorectal epithelial cells.Semantic proximity Read ↗

The landscape of somatic mutation in normal colorectal epithelial cellsSemantic proximity Read ↗

Somatic targeted mutation profiling of colorectal cancer precursor lesionsSemantic proximity Read ↗

Somatic targeted mutation profiling of colorectal cancer precursor lesions.Semantic proximity Read ↗

Molecular characterization of colorectal adenoma and colorectal cancer via integrated genomic transcriptomic analysisSemantic proximity Read ↗

Mutational Landscape of Colorectal Tumors From Individuals With Unexplained Adenomatous or Serrated Colorectal Polyposis.Semantic proximity Read ↗

Genomic landscape of colorectal carcinogenesis.Semantic proximity Read ↗

Cancer-Associated Mutations in Normal Colorectal Mucosa Adjacent to Sporadic Neoplasia.Semantic proximity Read ↗

The evolutionary landscape of colorectal tumorigenesis.Semantic proximity Read ↗

Whole-exome sequencing identified mutational profiles of high-grade colon adenomas.Semantic proximity Read ↗

Molecular characterization of colorectal adenomas with and without malignancy reveals distinguishing genome, transcriptome and methylome alterationsSemantic proximity Read ↗

Consensus molecular subtype classification of colorectal adenomas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.