Article

Somatic targeted mutation profiling of colorectal cancer precursor lesions

2021-04-20

Abstract excerpt

Most colorectal cancers (CRC) arise from precursor lesions. We aimed to characterize the mutation profile of CRC precursor lesions in a Brazilian population. In total, 90 FFPE lesions, including 67 adenomas, 7 sessile serrated lesions, and 16 hyperplastic polyps, were analyzed by next-generation sequencing. The genetic ancestry of the patients was estimated. Somatic driver mutations were identified in 66.7% of cas...

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Literature Corpus work: d3589305-2cc4-5267-bac8-e8b4042e8f3b
DOI: 10.21203/rs.3.rs-428174/v1

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