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Article

Adenoma development in familial adenomatous polyposis and MUTYH ‐associated polyposis: somatic landscape and driver genes

28 Sept 2015

Abstract excerpt

Familial adenomatous polyposis (FAP) and MUTYH-associated polyposis (MAP) are inherited disorders associated with multiple colorectal adenomas that lead to a very high risk of colorectal cancer. The somatic mutations that drive adenoma development in these conditions have not been investigated comprehensively. In this study we performed analysis of paired colorectal adenoma and normal tissue DNA from individuals...

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PMID: 26414517
DOI: 10.1002/path.4643

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